England scored eight tries in a rout, but Italy head coach Conor O'Shea said: "I wouldn't get too carried away with the scoreline."
Head coach Eddie Jones says England must look after themselves on what will be a tense final weekend of the Six Nations season.
Brett Connon held his nerve with a late penalty to give Newcastle victory at Wasps, while Exeter also did the Falcons a favour.
The Bulls went top of the South African Conference by brushing aside the Sharks as the Lions held off the Jaguares.
England responded to their Six Nations loss versus Wales with an emphatic defeat Italy, setting up an intriguing final weekend.
Gregor Townsend was left to reflect on a missed opportunity after Scotland failed to derail Wales' quest for a Grand Slam.
Scotland dominated the second half at Murrayfield and Warren Gatland admitted his Wales side got "a little bit lucky" as they prevailed.
Victory over Ireland in the final round of the Six Nations would secure a Grand Slam for Wales after Warren Gatland's men overcame Scotland.
The 2019 Rugby World Cup is set to represent Rory Best's swansong, with the hooker "fairly sure" he will retire following the tournament.
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