Captain Owen Farrell converted all four of England's tries and also kicked three penalties as his side eased past Italy on Friday.
Gregor Townsend may count the cost of injuries from Scotland's final Rugby World Cup warm-up victory over Georgia.
One of the best wings in South African rugby history, World Cup winner Chester Williams died on Friday.
Japan were unable to repeat their shock 2015 Rugby World Cup success over South Africa, largely due to Makazole Mapimpi's hat-trick.
The upcoming Rugby World Cup will mark David Pocock's last matches for the Wallabies.
Ireland have been boosted by the returns of Johnny Sexton, Conor Murray, Keith Earls and Robbie Henshaw for their meeting with Wales.
Wales have rung the changes against Ireland as they finish preparations for the Rugby World Cup.
Though he is not in the Rugby World Cup squad, Joe Marchant will start at centre against Italy in England's final warm-up game.
Set to make his 90th appearance for the Wallabies, veteran hooker Tatafu Polota-Nau is retiring from Tests at year's end.
Ireland's talisman Johnny Sexton says he was "blessed' to overcome a thumb injury in time to make Joe Schmidt's Rugby World Cup squad.
Hooker Stuart McInally has been selected to captain Scotland in Japan, though Huw Jones was the shock absentee from the squad list.
Pieter-Steph du Toit will make his 50th appearance for South Africa against Japan while Siya Kolisi will captain a strong team.
Jacques Brunel has finalised his France Rugby World Cup squad for a second time, leaving out Felix Lambey and Dany Priso.
There was a major shock in Georgia's Rugby World Cup squad announcement, with Mamuka Gorgodze coming out of retirement.
Ireland coach Joe Schmidt has named his squad for the Rugby World Cup, with experienced second row Devin Toner surprisingly missing out.
Australia centurion Sekope Kepu has announced he will retire from international rugby following the World Cup.