Lyon scored all five tries in the second half in a rout of Stade Francais, while Racing 92 claimed their fourth consecutive win.
Eddie Jones backed Owen Farrell after England's narrow victory against South Africa.
Clermont Auvergne could only draw with lowly Grenoble and Toulouse took advantage by putting Bordeaux-Begles to the sword in the Top 14.
Jordan Larmour grasped his first opportunity to start for Ireland with both hands, scoring three tries and laying on another in Chicago.
Warren Gatland saw room for improvement but was encouraged by the way Wales saw off Scotland to win the Doddie Weir Cup.
There were wins for Connacht and Ulster in Saturday's Pro14 action.
Eben Etzebeth suffered what appeared to be an ankle injury early in the second half of the Springboks' defeat against England.
South Africa dominated England in the second half, but Eddie Jones was pleased with the way his side hung in there and fought back.
South Africa paid the price for letting England off the hook at Twickenham, where Eddie Jones' men gained revenge for a series loss in...
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Wales started their November internationals with victory over Scotland, Jonathan Davies scoring on his return from a long injury lay-off.
Kieran Read wants to keep playing after the World Cup, which will likely mark the end of the All Blacks captain's international career.
Jordie Barrett made another mistake in the All Blacks' win over Japan, but Steve Hansen came to his defence.
There was no shortage of action in Tokyo as New Zealand beat Japan 69-31 in a contest featuring 15 tries.
Glasgow Warriors stretched their lead at the top of Conference A to nine points thanks to Nikola Matawalu's hat-trick against Ospreys.
Beauden Barrett will make history if he is named the best player in the world again, but he has some strong competition.
Manu Tuilagi has suffered yet another injury blow, a groin problem ruling him out of the showdown with South Africa.