Jordan Petaia will become Australia's youngest debutant for a decade in a much-changed side in Padova.
Full-back Rob Kearney and centre Garry Ringrose have recovered from injuries in time to start against New Zealand.
Wales coach Warren Gatland has made 14 changes for Saturday's international against Tonga, with Liam Williams selected for his 50th cap.
Joe Cokanasiga comes into the side as Eddie Jones makes 11 changes to the England team that started against New Zealand.
Steve Hansen has made just one enforced change for the All Blacks' showdown with Ireland, Ryan Crotty coming in for Sonny Bill Williams.
Gordon Reid will make his first Scotland appearance since March as one of six changes for their clash with South Africa.
Bath have been boosted by the news of new contracts for four players, including England star Anthony Watson.
Eddie Jones has named a 30-man squad for England's remaining two November Tests, with George Kruis missing due to injury.
Wales hope to have Tomas Francis and George North fit to face Tonga, but Samson Lee has left the camp with a hamstring injury.
Warren Whiteley's calf injury could keep him out of South Africa's clash with Scotland, but Eben Etzebeth may return.
Gary Graham was called up to the England Six Nations squad this year, but is set to win his first international cap for Scotland.
Sean O'Brien suffered another injury blow on Saturday, but Ireland coach Joe Schmidt says he has the resilience to make a quick return.
Stuart Hogg said the time has come to challenge himself in a different environment after nine seasons with Glasgow Warriors.
Wallabies and Waratahs back-rower Jack Dempsey re-signed until at least 2020.
Kieran Marmion should be fit to feature in Ireland's upcoming match against New Zealand, but Sean O'Brien will play no part.
Kieran Marmion, Bundee Aki and Luke McGrath crossed to give Ireland a largely unconvincing win over Argentina.