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Cian Healy will miss the remainder of the Six Nations after the prop was injured during Ireland's loss to England.
Josh Adams will miss the games against England and Scotland as he requires surgery on the ankle he injured against France.
The Ospreys have turned to Toby Booth to take over as head coach when he finishes his assignment with Harlequins.
Wales full-back Liam Williams has joined the Scarlets ahead of schedule, while Rhys Webb joined Bath ahead of a move to Ospreys.
Former New Zealand prop Ben Franks says the end of this season will be the right time to end his illustrious career.
Ardie Savea says a move to either Sydney Roosters or Melbourne Storm are options that appeal to the All Blacks flanker.
More Italian sporting fixtures have been delayed by the coronavirus, with Zebre & Benetton Treviso seeing matches postponed.
Southern Kings and Benetton Treviso both fell short on Welsh soil as Scarlets and Cardiff Blues earned Pro14 wins.
Lyon and Toulouse were both winners in Sunday's Top 14 action, with Patricio Fernandez impressing for the former.
England were quick out of the blocks against Ireland and Owen Farrell insists the team are happy with how things are "in-house".
Ireland were beaten 24-12 at Twickenham, with head coach Andy Farrell left to concede that England were much the better side.
Eddie Jones' team selection for England's crunch Six Nations clash with Ireland raised eyebrows, but his side responded in style on Sunday.
Exeter plundered eight tries in a crushing victory over Northampton as they took another step closer to finishing top of the Premiership.
Bordeaux Begles gave another demonstration of their Top 14 title credentials with a bonus-point win over Clermont Auvergne.
After losing to Ospreys, Ulster bounced back by defeating Cheetahs, while Glasgow Warriors beat Dragons to move into third in Conference A.
Wales look highly unlikely to retain their Six Nations title after a loss to France, but Wayne Pivac felt they were hard done by.
