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Scotland were wasteful against Ireland on Saturday, with Stuart Hogg apologetic as he departed Dublin following a huge missed opportunity.
Josh Adams plundered a hat-trick in Wales' rout of Italy, much to the delight of his boss Wayne Pivac.
Johnny Sexton has played only three matches since the Rugby World Cup, but Andy Farrell saw an "outstanding" display from Ireland's captain.
Ireland were below their best on Saturday but gave new head coach Andy Farrell a winning start against Scotland.
Forget talk of salary caps and World Cup hangovers, England need to deliver as title favourites in this year's Six Nations.
Joseph Dweba crossed twice as the Cheetahs ran in seven tries to beat Southern Kings again, albeit this time in emphatic fashion.
Wales opened the Six Nations by nilling Italy in Cardiff, Josh Adams and Dan Biggar starring for Wayne Pivac's side.
Super Rugby champions the Crusaders proved their class with an opening win, while the Rebels slumped to a poor loss in Japan.
Gregor Townsend maintained there is much more to come from Scotland after their World Cup failure, and they must step up in the Six Nations.
The Sharks ended a poor recent run against the Bulls with a 23-15 win over their South African rivals in Friday's Super Rugby clash.
Warren Gatland rung the changes with the Chiefs behind and was rewarded with victory, while the Brumbies also triumphed.
With Anthony Watson failing to overcome a calf problem, George Furbank has been handed a starting spot for England against France.
France are set for a new era at the Six Nations under head coach Fabien Galthie.
Wales begin the Wayne Pivac era on Saturday, and performing on the pitch remains as great a passion for male voice choirs as rugby players.
England and Scotland are the only sides without a new head coach for the 2020 edition of the Six Nations.
Ireland should be a major threat in the Six Nations at the start of a new era under head coach Andy Farrell.
