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England overlook Mako Vunipola as a coronavirus precaution, yet he will play for Saracens against Leicester Tigers.
The Brumbies rolled the Sunwolves 47-14, while the Reds came just short of the Crusaders in a 24-20 defeat and the Chiefs hammered home-side Waratahs 51-14...
England are expecting a tough battle against Wales and Eddie Jones believes last year's loss in Cardiff provides perfect motivation.
Wollongong set the stage for back-to-back Super Rugby clashes on Friday, with the Brumbies and the Chiefs enjoying victories.
Wales boss Wayne Pivac expects a "big performance" against England after stepping up intensity in training, epitomised by Alun Wyn Jones.
France head to Murrayfield scenting a Grand Slam and a first Six Nations title in a decade, while wounded Wales face England.
Wales have lost back-to-back Six Nations clashes and will face England at Twickenham on Saturday with a side showing four changes.
Italy have had a second Six Nations match postponed due to the coronavirus, with doubts over whether the tournament will be completed.
Mark Wilson and Anthony Watson replace Sam Underhill and Jonathan Joseph respectively in the England side to face Wales.
