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A new set of initiatives aimed at improving the welfare of players have been announced by the Rugby Football Union.
The need for Bradley Davies to manage a knee injury has led to him being released from the Wales squad.
Rebels have signed Reds outcast Quade Cooper, who will look to resurrect his Super Rugby career in 2019.
Thomas Waldrom has called time on a career that included five England caps and two Premiership titles.
Maxime Medard's late try proved crucial as Toulouse beat European Champions Cup holders Leinster on Sunday.
Reece Hodge's season is over after the versatile 24-year-old fractured his ankle in an Australia training session.
Connacht had no answer to Chris Ashton, who enjoyed a hat-trick on his competitive debut for Sale Sharks.
Wasps, without Christian Wade, battled back to draw with Bath, and Edinburgh battered Toulon in Saturday's European Champions Cup action.
Christian Wade has been heavily linked with a career switch to the NFL, but Wasps boss Dai Young insists for now it is mere speculation.
Gloucester could be set for a prolonged spell without Danny Cipriani, who was shown a red card for a high shot on Munster's Rory Scannell.
Having been beaten 82-21 by La Rochelle six days earlier, Enisei were once again outplayed by the French club.
Wasps have not made any comment on reports that Christian Wade, who will not play against Bath, is set for a sensational move to the NFL.
Courtney Lawes had been linked with a move to the Top 14, but the long-serving lock will be staying at Franklin's Gardens.
Danny Cipriani's fine form has not been enough to earn and England recall, with coach Eddie Jones identifying room for improvement.
Ben Morgan has not played for England since the last World Cup, but the number eight is set to make his Test comeback next month.
England will be without Nathan Hughes for three of their November internationals after he was banned for six weeks.
