Ireland will assess their performance after they survived a late scare to beat Wales 37-27 at the Aviva Stadium.
The Premiership saw its first draw of the season, while leaders Exeter Chiefs and Bath were winners by a solitary point on Saturday.
Ireland outscored Wales by five tries to three in Dublin to make it three Six Nations wins out of three.
Defending champions the Crusaders scored seven tries to get start their Super Rugby season with a hard-fought win over the Chiefs.
Scotland have not beaten England for a decade and Lee Mears does not expect them to put that right at Murrayfield.
Former England lock Simon Shaw says facing Scotland at Murrayfield will be a "very tough proposition" for the Six Nations holders.
England cannot afford to give Scotland the scent of victory in the closing stages at Murrayfield, says Martin Johnson.
Rob Harley's record 178th appearance for Glasgow Warriors was one to forget as they were beaten by Munster.
France ended their wait for a first win in the Six Nations, eventually easing past Italy 34-17 at the Stade Velodrome.
England have not lost to Scotland for a decade and John Barclay knows his side face a "big challenge" to end that dismal run.
Rory Best believes Johnny Sexton will start for Ireland despite him receiving treatment on his back on Friday.
The Rebels only won one Super Rugby match last year, but they have already matched that tally after beating the Reds at AAMI Park.
Eddie Jones has turned England into a major force, but said to himself "Goodness me, what have I got myself into here?" early in... Read more
Owen Farrell missed some training sessions ahead of England's Six Nations meeting with Scotland but Eddie Jones has cast aside any concerns.
Wales will be coached by Warren Gatland for the 100th time on Saturday and we have crunched the numbers behind his tenure.
Injuries have forced a reshuffle for Ireland coach Joe Schmidt, who makes five changes for the Six Nations clash with Wales.