Pieter-Steph du Toit will make his 50th appearance for South Africa against Japan while Siya Kolisi will captain a strong team.
Jamie Joseph has named host nation Japan's squad for the Rugby World Cup, with uncapped Takuya Kitade selected.
Eddie Jones had urged England to "smash" Japan and he thinks those comments were ringing in the Brave Blossoms' ears at Twickenham.
Japan led 15-10 at half-time, but England scored three tries after the interval to avoid a huge upset at Twickenham.
Joe Cokanasiga comes into the side as Eddie Jones makes 11 changes to the England team that started against New Zealand.
Eddie Jones has named a 30-man squad for England's remaining two November Tests, with George Kruis missing due to injury.
An ankle problem will keep Sale Sharks flanker Tom Curry sidelined for England's Tests against New Zealand, Japan and Australia.
Jordie Barrett made another mistake in the All Blacks' win over Japan, but Steve Hansen came to his defence.
There was no shortage of action in Tokyo as New Zealand beat Japan 69-31 in a contest featuring 15 tries.
Australia will be determined to end their tour with a morale-boosting win over England after a barren run against their rivals.
With Jamie Joseph focusing on Japan ahead of the 2019 Rugby World Cup, Tony Brown will be in charge of the Sunwolves in Super... Read more
A pair of late Tommaso Allan penalties proved vital for Italy as, unlike in the first Test, Japan's second-half surge could not earn a... Read more
An excellent second half helped Japan beat Italy in Oita, the Brave Blossoms taking a 1-0 lead in the two-match series.