Runners-up last season, the Jaguares ran away with a comfortable win over the Lions.
Aphiwe Dyantyi has been formally charged with a doping violation by the South African Institute for Drug-Free Sport.
A dramatic 12-9 win over the Stormers secured the Sharks' spot in the Super Rugby play-offs, where they will be joined by the Bulls.
South Africa hooker Malcolm Marx will make a short-term move to Japan after the Rugby World Cup before returning to the Lions.
The Lions are used to reaching the Super Rugby showpiece match but a 37-17 defeat to the Hurricanes has endangered their play-off hopes
Number eight Warren Whiteley hopes to play some part in the Currie Cup to prove his fitness ahead of the Rugby World Cup.
The Lions overcame South African rivals Stormers 41-22 in an exhilarating Super Rugby clash in Johannesburg.
Springboks playmaker Elton Jantjies will miss the Lions' Super Rugby meeting with the Stormers due to a "breach of team protocol".
The Blues have now suffered 10 consecutive losses to the Crusaders after Super Rugby's leaders edged a tense Christchurch encounter.
The Lions' moved into a Super Rugby play-off berth with a narrow 29-28 success over the Waratahs in Johannesburg.
Sevu Reece and George Bridge scored twice as the Crusaders outclassed the Lions in Super Rugby on Friday.
A second-half fightback was needed for the Hurricanes to avoid a shock defeat to the Sunwolves in Super Rugby.
Lachlan Boshier crossed twice as the Chiefs overcame the Blues in Hamilton. In Canberra, the Brumbies were 31-20 winners over the Lions.
The Lions' three-match winning run in Super Rugby was ended in incredible fashion as the Sharks ran riot in Johannesburg.
Swys de Bruin has been given a new deal with the Lions to remain as head coach of the Johannesburg franchise until 2021.
Crusaders lost for the first time since March last year as Israel Folau secured a piece of Super Rugby history in a Waratahs win.