The Chiefs beat the Blues even without a host of players due to injury, while the Reds triumphed despite two key suspensions.
La Rochelle are a formidable force on home soil, but suffered a rare defeat at Stade Marcel-Deflandre as Toulon came from behind to win.
Saracens fell victim to a tremendous Leicester Tigers performance on Sunday, while there was a rare win for London Irish against Worcester.
A Jarrod Evans penalty on the stroke of half-time and Owen Lane's converted try gave Cardiff Blues a hard-fought win at Zebre.
Agen and Oyonnax secured rare wins at the foot of Top 14, while Montpellier enjoyed another successful day at the top.
Leinster's big win on Saturday did not quell Scarlets as they kept pace in the Pro14, while Benetton Treviso's promising form was ended.
Star performances from Aphiwe Dyantyi and Pierre Schoeman earned victories for the Lions and the Bulls in Saturday's Super Rugby action.
Murrayfield was treated to a rare Scottish success over England, with Huw Jones scoring two tries and Finn Russell delivering a fine game.
The Premiership saw its first draw of the season, while leaders Exeter Chiefs and Bath were winners by a solitary point on Saturday.
Ireland outscored Wales by five tries to three in Dublin to make it three Six Nations wins out of three.
Defending champions the Crusaders scored seven tries to get start their Super Rugby season with a hard-fought win over the Chiefs.
Rob Harley's record 178th appearance for Glasgow Warriors was one to forget as they were beaten by Munster.
France ended their wait for a first win in the Six Nations, eventually easing past Italy 34-17 at the Stade Velodrome.
The Rebels only won one Super Rugby match last year, but they have already matched that tally after beating the Reds at AAMI Park.