Stuart Hogg has been ruled out for 10 to 12 weeks, meaning the Glasgow Warriors star is set to miss all four of Scotland's November Tests.
After negotiating an exit from his contract with Scotland, Dan McFarland will take the head coaching reins at Ulster.
Although contracted for another year, Alasdair Dickinson has called time on his rugby career, switching to a coaching role.
Gregor Townsend has signed a one-year contract extension following an impressive start to his tenure as Scotland head coach.
Tim Swinson did damage just five minutes into Scotland's drubbing of Argentina last weekend and has gone under the knife in his homeland.
Shaun Wane will switch codes to work with elite coaches at all levels on a consultancy basis with Scottish Rugby.
Scotland claimed their largest away victory over Argentina as brothers George and Peter Horne inspired them to a 44-15 win on Saturday.
Stuart McInally returns to the Scotland starting XV after Gregor Townsend makes eight changes to the side that lost in the second Test.
Danny Wilson's move to Wasps is no longer happening as the club reached an agreement with Scotland for him to be Greg Townsend's assistant.
Scotland became the first tier-one nation to be defeated by USA after a 30-29 loss in Houston on Saturday.
Scotland outclassed Canada in their Test match as George Turner crossed for a hat-trick.
Toulouse's Richie Gray has joined Alex Dunbar in pulling out of the Scotland squad for their June fixtures.
Mark Bennett has been called into Scotland's squad for their June Test matches to replace the injured Alex Dunbar.
John Barclay has been denied the chance to end his Scarlets career with a Pro14 final appearance, after rupturing his Achilles.
Stuart McInally will step up to lead Scotland on their end-of-season tour, with John Barclay given a rest.
Tim Visser said playing for Scotland has been the biggest honour of his life after calling time on his international career.