Handre Pollard scored 18 points as South Africa became only the second side in 12 matches to beat Scotland at Murrayfield.
With Faf de Klerk on club duty with Sale Sharks, Embrose Papier will make his first South Africa start on Saturday.
Gordon Reid will make his first Scotland appearance since March as one of six changes for their clash with South Africa.
Warren Whiteley's calf injury could keep him out of South Africa's clash with Scotland, but Eben Etzebeth may return.
Mbongeni Mbonambi's try right at the end consigned France to defeat after they led South Africa by 14 points in Paris.
South Africa rallied from a 14-point deficit in the second half to secure a thrilling Test victory over France in Paris.
South Africa are able to call up European-based players against France, leading to the returns of three experienced stars.
Jacques Brunel has recalled Louis Picamoles and Camille Lopez to face the Springboks at Stade de France.
Eben Etzebeth's foot injury is not as bad as first feared and he could yet play against France in Paris.
Owen Farrell has avoided suspension following his heavy hit on Andre Esterhuizen in England's win over South Africa.
Eddie Jones backed Owen Farrell after England's narrow victory against South Africa.
Eben Etzebeth suffered what appeared to be an ankle injury early in the second half of the Springboks' defeat against England.
South Africa dominated England in the second half, but Eddie Jones was pleased with the way his side hung in there and fought back.
South Africa paid the price for letting England off the hook at Twickenham, where Eddie Jones' men gained revenge for a series loss in June.
Beauden Barrett will make history if he is named the best player in the world again, but he has some strong competition.
Manu Tuilagi has suffered yet another injury blow, a groin problem ruling him out of the showdown with South Africa.