England were made to pay for an error-strewn performance in Paris, where France enjoyed a winning start to the Six Nations.
After England coach Eddie Jones questioned their Test credentials ahead of the Six Nations clash, France let their rugby do the talking.
Captain Owen Farrell said there were no excuses for England after they were beaten by France in Paris.
Charles Ollivon led from the front with a double in his first game as captain as France beat England at the start of a new dawn.
France produced a dazzling opening 40 minutes to lead England 17-0 in Paris, Vincent Rattez and Charles Ollivon both scoring tries.
Runners-up last season, the Jaguares ran away with a comfortable win over the Lions.
Scotland were wasteful against Ireland on Saturday, with Stuart Hogg apologetic as he departed Dublin following a huge missed opportunity.
Josh Adams plundered a hat-trick in Wales' rout of Italy, much to the delight of his boss Wayne Pivac.
Johnny Sexton has played only three matches since the Rugby World Cup, but Andy Farrell saw an "outstanding" display from Ireland's captain.
Ireland were below their best on Saturday but gave new head coach Andy Farrell a winning start against Scotland.