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Mako Vunipola's return from injury was cut short, but England coach Eddie Jones is "cautiously optimistic" over the prop.
The Rugby World Cup is not far away but Ireland's performance against England showed they are not ready, according to Rory Best.
Ireland's hopes of moving to the top of the world rankings on Saturday were crushed by a brilliant England display at Twickenham.
Sam Skinner, Tommy Seymour and Blade Thomson were forced off as Scotland hit back to beat France a week after a heavy defeat.
The fixtures for the 2019-20 Champions Cup and Challenge Cup have been revealed, with Saracens starting their title defence at Racing 92.
Despite being seen as a potential successor to Eddie Jones, Jim Mallinder is leaving his role with England for a job in Scotland.
David Pocock has not played since March but Michael Hooper expects him to be key for Australia at the Rugby World Cup.
Jordan Petaia, 19, is the only uncapped Australia player in Michael Cheika's squad for the showpiece event, which starts on September 20.
For the first time in over a year, George Ford and Owen Farrell will be in England's starting line-up when they face Ireland.
Ross Byrne will start Ireland's meeting with England at fly-half as Johnny Sexton and Joey Carbery struggle with injury.
