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La Rochelle put Pau to the sword and Castres also enhanced their chances of reaching the play-offs with a win in Bordeaux.
Glasgow Warriors celebrated the news that head coach Dave Rennie will stay at the club by securing a famous win over Leinster in Dublin.
Worcester Warriors and Bristol Bears eased their relegation fears, leaving Newcastle Falcons needing a great escape to avoid the drop.
The Sharks gave another demonstration of their inconsistent at Kings Park, where the Jaguares ran riot with a seven-try drubbing.
Lachlan Boshier crossed twice as the Chiefs overcame the Blues in Hamilton. In Canberra, the Brumbies were 31-20 winners over the Lions.
Newcastle Falcons are running out of time to save themselves from Premiership relegation after losing at home to Leicester Tigers.
Edinburgh's Pro14 play-off hopes hang by a thread after a damaging home defeat to Ulster, who extended their own domestic season.
Billy Vunipola's support of Israel Folau has been condemned by the Rugby Football Union and Saracens.
Ben Smith marked a milestone appearance with an early try for the Highlanders, but they were soon swept away by the Crusaders.
Israel Folau is set to be sacked for his controversial social media posts, but Billy Vunipola has sympathy for the dual-code international.
