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Italy captain Sergio Parisse will make his 68th Six Nations appearance when the Azzurri face England on Saturday.
Ali Price replaces captain Greig Laidlaw as one of four changes to the Scotland side to take on leaders Wales.
Eddie Jones has made five changes to the England team to take on Italy, Joe Cokanasiga and Ben Te'o among the players coming in.
The Six Nations and Rugby Championship could introduce promotion and relegation as part of planned changes to the international game.
The back-and-forth between the Ospreys, Scarlets and PRB continued on Wednesday, with the Swansea region alleging a "stitch-up".
A look back at the best facts and stats from Kieran Read's career, as he prepares to step down from New Zealand duty.
The Scarlets say the Ospreys approached them last December regarding a possible merger, but the plans have been scrapped.
Kieran Read had been linked with Racing 92 and a Premiership switch, but said it was a "pretty straightforward" decision to move to Japan.
Kieran Marmion and Ross Byrne have been named in the Ireland squad ahead of the clash with France, but Robbie Henshaw and Dan Leavy are out.
New Zealand head coach Steve Hansen says Kieran Read has enhanced the legacy of the All Blacks jersey in a "remarkable" career.
