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England wing Chris Ashton will make his first Six Nations start since 2013 when France visit Twickenham on Sunday.
Romain Ntamack drops to the bench as Mathieu Bastareaud returns to face England in one of six changes to the France side.
Scotland can expect an Ireland backlash at Murrayfield, while England and Wales head into round two on a high after making winning starts.
Injuries to Garry Ringrose and Robbie Henshaw will allow Chris Farrell to return to the Ireland XV this weekend.
With the Rugby World Cup to come later this year, Warren Gatland has used the second week of the Six Nations to get to know his...
Conor O'Shea has made two changes to his Italy XV ahead of hosting Wales, with Edoardo Padovani and Nicola Quaglio coming in.
Ireland will have to do without Robbie Henshaw when they take on Scotland, so Chris Farrell comes into the side at Murrayfield.
Blair Kinghorn was not able to keep his place in the Scotland side to take on Ireland, with the experienced Sean Maitland taking his spot.
Warren Gatland has made 10 changes to his starting line-up for the clash against Italy, with Jonathan Davies named as captain.
David Wessels will remain in charge of the Rebels until 2021 after the Super Rugby franchise extended his deal.
