The return of Stuart Hogg slightly eases Scotland's concerns, while Greig Laidlaw and Finn Russell also start against Fiji.
South Africa are able to call up European-based players against France, leading to the returns of three experienced stars.
Rassie Erasmus has named his Springbok side to face France, inducing six overseas based players, who were previously unavailable for the English test. The integral trio...
Having rested key men against Italy, Joe Schmidt is back to a team somewhere near full strength as Rory Best captains Ireland.
Hooker Tolu Latu's indiscipline in his last two Tests has not deterred Michael Cheika from starting the hooker against Wales.
Warren Gatland brought Tomas Francis, Adam Beard and Josh Adams into his side to face Australia, with Dan Biggar and Liam Williams benched.
Wing Chris Ashton is preferred to Jack Nowell against the All Blacks as Eddie Jones makes three changes to his side.
Jacques Brunel has recalled Louis Picamoles and Camille Lopez to face the Springboks at Stade de France.
Ryan Crotty drops to the bench to make way for Jack Goodhue at Twickenham, while Joe Moody's tour is over due to an horrific eye injury.
Wales take on Australia on Saturday but Jamie Roberts says the match will not be an indication of how the teams perform at the World Cup.