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Eddie Jones has lost another influential figure in the back-row, with former captain Chris Robshaw out for up to eight weeks.
The unfortunate Billy Vunipola is expected to be out until January after he was injured in Saracens' win over Glasgow Warriors.
Wasps forward Joe Launchbury will be out for up to three months after the club confirmed he had surgery on his injured knee.
Sale Sharks have suffered a blow with the news Marland Yarde ruptured ligaments, as well as dislocating his left knee, on Saturday.
Sam Simmonds will be forced to sit on the sidelines until well into 2019 after suffering a serious knee injury.
Prop Joe Marler said comments he made on a podcast about looking for an "easy way out" of England duty were taken out of context.
Harlequins forward Joe Marler said it was "a very difficult decision" to end his England career at the age of 28.
England attack coach Scott Wisemantel said Danny Cipriani was still a chance to feature in the November internationals.
John Mitchell is sure England can conquer New Zealand and win the 2019 Rugby World Cup.
Manu Tuilagi and Chris Ashton will join up for England training in Bristol, but Danny Cipriani has been left out.
With one year to go until the 2019 Rugby World Cup, Omnisport takes a look at five tournament debutants who could impress in Japan.
England's new defence coach will be former assistant John Mitchell, who previously led New Zealand in 28 Tests.
Flanker Brad Shields will start his first Premiership game on Saturday when Wasps host last season's beaten finalists Exeter Chiefs.
Danny Cipriani may have been arrested while away with Gloucester last month, but Eddie Jones is still considering him for England selection.
Dylan Hartley has been called a "brilliant captain" by Owen Farrell, who led England in the hooker's absence during the South Africa tour.
England wing Chris Ashton's red card for Sale Sharks has landed him with a seven-week ban.
