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Sean O'Brien, Tadhg Beirne and Rob Kearney come in for Ireland as Joe Schmidt makes three changes against Wales.
Warren Gatland has gone with a tried and trusted starting XV as Wales chase Grand Slam glory against Ireland in the Six Nations.
Wales, England and Ireland all head into the final weekend of the Six Nations season with a chance to secure the title.
Flanker Josh van der Flier will play no part in Ireland's attempt to deny Wales a Grand Slam this weekend.
Ireland superstar Johnny Sexton has pointed to recent big results against New Zealand and England as evidence that they can defeat Wales.
Tommy Seymour, Blair Kinghorn and Stuart Hogg will miss Scotland's final Six Nations match, while France will also be without two players.
Ireland's bonus-point win over France was Joe Schmidt's final home Six Nations game at the helm and he was feeling emotional afterwards.
Ireland's bonus-point win over France kept them in the hunt to defend their title in what will be Rory Best's final Six Nations outing.
Joe Schmidt's Ireland earned a bonus point in their win over France to ensure the Six Nations finale will feature a three-way title tussle.
Head coach Eddie Jones says England must look after themselves on what will be a tense final weekend of the Six Nations season.
The 2019 Rugby World Cup is set to represent Rory Best's swansong, with the hooker "fairly sure" he will retire following the tournament.
Josh van der Flier takes Sean O'Brien's place and Rory Best returns to captain a much-changed Ireland side against France.
The fourth round of fixtures in the 2019 Six Nations sees Wales visit Scotland, England take on Italy and Ireland host France.
Kieran Marmion and Ross Byrne have been named in the Ireland squad ahead of the clash with France, but Robbie Henshaw and Dan Leavy are out.
Joey Carbery and Andrew Conway could feature against France this weekend, but Robbie Henshaw and Dan Leavy may be absent.
Jacques Brunel has unsurprisingly stuck with the same 23 to take on the defending champions after an impressive display against Scotland.
