Injuries have forced a reshuffle for Ireland coach Joe Schmidt, who makes five changes for the Six Nations clash with Wales.
As the leading sides in Europe do battle in the Six Nations, we preview the third round of matches.
As expected, the fit-again Nathan Hughes starts for England against Scotland in the Six Nations, while Joe Marler returns to the bench.
England have not yet hit top gear in the Six Nations and Mike Tindall wants them to go on the offensive at Murrayfield.
Mike Tindall and Olivier Magne were among the former rugby stars putting on a show in the Tournoi des 6 Stations Orangina.
Conor O'Shea has made three alterations to his side for Italy's Six Nations encounter with France in Marseille.
Two years after leaving for Gloucester, Matt Scott is to return to Pro14 with hometown club Edinburgh.
Johan Ackermann and son Ruan will face no further police action over a nightclub incident, a decision Gloucester Rugby have welcomed.
After defeating France last time out in the Six Nations, Scotland are unchanged for England's visit to Murrayfield.
There will be five changes for France's line-up in the Six Nations clash with Italy, including a return for Mathieu Bastareaud.
Wales head coach Warren Gatland wants his players to be "pretty physical" when they come up against Jonathan Sexton and Conor Murray.
Olivier Magne says French rugby must establish an identity if the national team is to have any chance of challenging for honours.
Warren Gatland takes charge of Wales for the 100th time and hands recalls to fit-again trio Dan Biggar, Leigh Halfpenny and Liam Williams.
Garry Ringrose is back in contention for Ireland as they prepare to face Wales in the Six Nations.