Exeter Chiefs reached their first European Champions Cup final at Toulouse's expense after Racing 92 dumped Saracens out.
Holders Saracens are a win away from the Champions Cup final after beating Leinster, while Racing 92 powered past Clermont Auvergne.
Kurtley Beale and Luke Jones are returning to Europe to join top 14 heavyweights Racing 92 next year.
Lyon and Toulouse were both winners in Sunday's Top 14 action, with Patricio Fernandez impressing for the former.
Racing 92 stretched their Top 14 winning run to five matches with a dramatic defeat of Toulouse.
There were reports Saracens faced expulsion from the European Champions Cup, but the holders have been hit with a fine.
Saracens will discover in London on Friday whether they will face any action for picking Titi Lamositele against Racing 92.
The mercurial Finn Russell has been punished for a breach of team protocol just nine days before Scotland's first Six Nations game.
Championship-bound Saracens will be without Will Skelton until the end of next month following his dismissal last weekend.
A thrashing of Lyon ensured Leinster made it five wins from five in the European Champions Cup, while Racing 92 reached the last eight.
Fiji forward Leone Nakarawa will return to Glasgow Warriors for the rest of the season, subject to obtaining a visa and passing a medical.
There were wins for Lyon and Racing 92 in the Top 14 as Bordeaux-Begles were usurped at the summit.
Juan Imhoff scored two of Racing 92's six tries as they beat Ospreys 40-27 to increase their lead at the top of Pool 4.
Leone Nakarawa has been linked with a return to Glasgow Warriors after Racing 92 announced they had sacked their star lock on Friday.
Racing 92, Northampton Saints and Connacht were all winners in Sunday's European Rugby Champions Cup action.
Wing Teddy Thomas put more pressure on Stade Francais coach Heyneke Meyer as Racing 92 came out on top in the Paris derby.