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Johnny Sexton left Ireland's Six Nations win over Scotland with a head injury and Joe Schmidt hopes he will recover in time to face Italy.
Scotland were beaten by Ireland at Murrayfield in the Six Nations on Saturday and head coach Gregor Townsend felt he was to blame.
Tries from Conor Murray, Jacob Stockdale and Keith Earls saw Ireland victorious at Scotland, giving Rory Best encouragement.
Captain Greig Laidlaw felt French official Romain Poite did not do Scotland any favours in the loss to Ireland.
Conor Murray, Jacob Stockdale and Keith Earls crossed for tries as Ireland got up and running in the Six Nations at Murrayfield.
Scotland can expect an Ireland backlash at Murrayfield, while England and Wales head into round two on a high after making winning starts.
Injuries to Garry Ringrose and Robbie Henshaw will allow Chris Farrell to return to the Ireland XV this weekend.
Ireland will have to do without Robbie Henshaw when they take on Scotland, so Chris Farrell comes into the side at Murrayfield.
Blair Kinghorn was not able to keep his place in the Scotland side to take on Ireland, with the experienced Sean Maitland taking his spot.
Ireland will have to do without Garry Ringrose and Devin Toner at Murrayfield when they attempt to hit back from their defeat to England.
A rare Aviva Stadium defeat was painful for Ireland, yet Peter O'Mahony said: "We can't be hanging around feeling sorry for ourselves."
British and Irish Lions back-row CJ Stander has been ruled out of Ireland's next two Six Nations matches.
Fraser Brown and Murray McCallum have been added to Scotland's Six Nations squad, with injury concerns over Sam Skinner and Willem Nel.
Italy were well beaten by Scotland, but Greig Laidlaw knows his team must ensure they perform for the full 80 minutes.
Scotland were comfortable winners over Italy in their Six Nations opener, with Blair Kinghorn registering his first international hat-trick.
Italy captain Sergio Parisse has now played in more Six Nations matches than any other player, after starting against Scotland.
