The Sharks recorded a home win over the Rebels, while the Chiefs cruised to victory against the Bulls to kickstart their Super Rugby season.
Crusaders lost for the first time since March last year as Israel Folau secured a piece of Super Rugby history in a Waratahs win.
An emotional tribute was paid to the victims of Christchurch's terrorist attack before the Crusaders and Waratahs played in Super Rugby.
Waratahs and Australia star Israel Folau secured a piece of Super Rugby history with his 59th try in the competition.
For the first time since February 2016, the Blues claimed a Super Rugby win over a fellow New Zealand side as the Highlanders were beaten.
Super Rugby will be reduced from 15 sides to 14 in 2021, with the Tokyo-based Sunwolves bowing out at the end of the 2020 season.
John Barclay will be looking to make up for lost time when he comes up against the European champions on Friday.
Saturday's clash between the Waratahs and the Crusaders will see the latter play their first match since the Christchurch attacks.
It has been reported in Australia that the Sunwolves may not be part of Super Rugby's future and matters should be clarified this week.
The Crusaders want to ensure they are respectful and allow people to grieve amid talk of the Super Rugby champions changing their name.
Harlequins will be looking for the man nicknamed 'The Door Opener', Martin Landajo, to unlock Premiership defences.
As the Rebels looked to be cruising towards a big away win, the Lions rallied and sensationally stole victory on Saturday.
The Reds came storming back in the second half of Saturday's Super Rugby clash to beat the Sunwolves, scoring four tries after the interval.
Saturday's game between the Highlanders and Crusaders has been called off following the Christchurch terror attacks.
The Jaguares started well and caused the Stormers problems throughout on Friday but were ultimately soundly beaten.
The Chiefs halted their losing run by drawing an entertaining derby with the Hurricanes, while the Brumbies saw off the Waratahs.