Wales full-back Leigh Halfpenny will play for the first time since November when the Scarlets take on the Cheetahs.
Warren Gatland says it will be a "big challenge" for Kyle Sinckler to avoid getting in hot water at the Principality Stadium.
The third round of fixtures in the 2019 Six Nations sees Wales host England, Scotland visit France, and Ireland head to Italy.
Eddie Jones described Warren Gatland's team as "the greatest Welsh side ever", but the Wales coach does not agree.
Gareth Anscombe gets the nod at number 10 in a much-changed Wales side for a huge encounter with England.
Mako Vunipola and Chris Ashton are replaced by Ben Moon and Jack Nowell in England's starting line-up to take on Wales.
England's Steve Borthwick has confirmed that Maro Itoje will be absent again when they travel to Wales on Saturday.
Wales are hopeful that Leigh Halfpenny and Dan Biggar will recover in time to face England in the Six Nations on Saturday.
A minor calf strain means Chris Ashton will miss England's trip to face Wales in the Six Nations.
Wales were dealt a blow on Friday as Leigh Halfpenny's expected comeback for the Scarlets did not come to fruition.
Eddie Jones sought to dismiss Wales' strong record in Cardiff ahead of England's Six Nations visit, but Neil Jenkins is not worried.
Matthew Rees is eager to end his long career on a high note by securing a European Rugby Champions Cup spot for Cardiff Blues.
A back injury has ended Scott Williams' hopes of participating in Wales' Six Nations campaign.
Bath have announced that Taulupe Faletau will undergo further surgery on his right arm, which will make him unavailable for Wales.
Leigh Halfpenny has been out since November after suffering a concussion, but could make his Wales comeback against England in Cardiff.
England may be top of the Six Nations table after two bonus-point wins, but Eddie Jones is wary of a Wales team that has won 11...