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Injuries sustained by Garry Ringrose and Caelan Doris open the door for Robbie Henshaw and Peter O'Mahony to start against Wales.
Ahead of crunch Six Nations matches with Wales and England, Ireland were dealt a blow with Garry Ringrose ruled out.
Josh Adams plundered a hat-trick in Wales' rout of Italy, much to the delight of his boss Wayne Pivac.
Wales opened the Six Nations by nilling Italy in Cardiff, Josh Adams and Dan Biggar starring for Wayne Pivac's side.
Wales begin the Wayne Pivac era on Saturday, and performing on the pitch remains as great a passion for male voice choirs as rugby players.
Josh Navidi is set to miss the majority of the Six Nations, while George North shifts to centre for Wales' first match of the tournament.
Wayne Pivac is hoping Liam Williams will make his comeback from an ankle injury in the second round of the Six Nations against Ireland.
Steff Evans was linked with a move to the Top 14, but the Wales flyer has decided to remain with his home region.
Super Rugby team the Stormers received financial support from a corporate partner to sign Jamie Roberts from Bath.
Louis Rees-Zammit, the 18-year-old Gloucester flyer, could make his Wales debut in the Six Nations in a new era under Wayne Pivac.
Ospreys were boosted by George North's return but still could not see off Dragons in Pro14.
Liam Williams will return to Pro14 side Scarlets next season after his contract with Premiership champions Saracens comes to an end.
Reports have claimed Liam Williams will leave Saracens to rejoin Scarlets, and the Wales full-back seems to have confirmed the move.
The Ospreys have confirmed Owen Watkin is facing up to eight weeks on the sidelines, ruling him out of the start of the Six Nations.
Rob Howley placed 363 bets across a 46-month period from November 2015 and has said sorry after being hit with a lengthy ban.
After placing 363 bets across a 46-month period from November 2015, Rob Howley has been handed an 18-month ban from rugby.
