Johnny Sexton has played only three matches since the Rugby World Cup, but Andy Farrell saw an "outstanding" display from Ireland's captain.
Ireland were below their best on Saturday but gave new head coach Andy Farrell a winning start against Scotland.
Forget talk of salary caps and World Cup hangovers, England need to deliver as title favourites in this year's Six Nations.
Joseph Dweba crossed twice as the Cheetahs ran in seven tries to beat Southern Kings again, albeit this time in emphatic fashion.
Wales opened the Six Nations by nilling Italy in Cardiff, Josh Adams and Dan Biggar starring for Wayne Pivac's side.
Super Rugby champions the Crusaders proved their class with an opening win, while the Rebels slumped to a poor loss in Japan.
Gregor Townsend maintained there is much more to come from Scotland after their World Cup failure, and they must step up in the Six Nations.
The Sharks ended a poor recent run against the Bulls with a 23-15 win over their South African rivals in Friday's Super Rugby clash.
Warren Gatland rung the changes with the Chiefs behind and was rewarded with victory, while the Brumbies also triumphed.
With Anthony Watson failing to overcome a calf problem, George Furbank has been handed a starting spot for England against France.