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Saracens knew they would be relegated at the end of the season, and a 70-point penalty ensures they will finish bottom of the Premiership.
Johnny Sexton and Jordan Larmour have been joined by uncapped number eight Caelan Doris in Ireland's team to face Scotland.
Ed Griffiths agreed to lead Saracens for 12 months but leaves the Premiership club just weeks after embarking on his second spell in charge.
Mark Keohane, on IOL, writes that while the name of the Bok coach has changed, nothing really has changed with World Cup-winning coach Rassie Erasmus still...
Bordeaux-Begles, nudged into second on Saturday, could not return to the Top 14 summit at Toulouse.
In their first Premiership outing since their automatic relegation was confirmed, Saracens were soundly beaten by London rivals Harlequins.
Top 14 front-runners Lyon won again, while La Rochelle's Arthur Retiere grabbed a hat-trick and Brive left it late.
Rhyno Smith scored twice in the closing stages against Southern Kings to again secure the bragging rights for the Cheetahs.
Exeter Chiefs rallied in the second half against Sale Sharks, but the Premiership leaders still slipped to a first defeat since November.
Northampton Saints looked to be heading top of the Premiership until London Irish sprung a shock following Api Ratuniyarawa's dismissal.
