The Crusaders were far too good for the Chiefs on Saturday, while the Blues claimed a first win in 2019 and the Waratahs beat the Reds.
Saracens suffered a second defeat in three at Bath, while Sale Sharks piled on the agony for Leicester Tigers.
Lewis Moody says England will be wounded from a defeat to Wales that he says should never have happened.
Scott Hastings says it is time Scotland did themselves justice when they face Six Nations leaders Wales at Murrayfield.
Captain Alun Wyn Jones says the Wales squad have been affected by talk of a merger between the Scarlets and the Ospreys, which is now off.
Josh van der Flier takes Sean O'Brien's place and Rory Best returns to captain a much-changed Ireland side against France.
The Hurricanes lead the way in Super Rugby after a 25-22 win over the Highlanders, while the Rebels triumphed 29-26 against the Brumbies.
Responding to a newspaper report, Rugby Australia says it has no record of a match-fixing probe into a Wallabies game.
The fourth round of fixtures in the 2019 Six Nations sees Wales visit Scotland, England take on Italy and Ireland host France.
Joe Cokanasiga will be unleashed from the start against Italy at Twickeham and Lewis Moody thinks the wing can make a big impact.