Sean O'Brien, Tadhg Beirne and Rob Kearney come in for Ireland as Joe Schmidt makes three changes against Wales.
England have made four changes for their Six Nations clash with Scotland, with Joe Cokanasiga surprisingly omitted from the squad.
Conor O'Shea has handed Marco Zanon his Italy debut as one of five changes for their Six Nations clash with France.
Scotland's hopes of retaining the Calcutta Cup have been boosted by the return of Sam Skinner for Saturday's clash with England.
Warren Gatland has gone with a tried and trusted starting XV as Wales chase Grand Slam glory against Ireland in the Six Nations.
Super Rugby weekend teams for round 5. The Stormers prepare for a physical encounter with the Jaguares, as the Argentinians are bolstered with the return of...
Wesley Fofana will start in his final Six Nations match as France travel to Italy looking for their second win of the 2019 tournament.
Wales, England and Ireland all head into the final weekend of the Six Nations season with a chance to secure the title.
Leicester Tigers have confirmed England centre Manu Tuilagi has signed a new deal with the Premiership club.
Former captain Sam Warburton has praised Warren Gatland for turning Wales into a world force during his near 12 years in charge.