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Wales came from 10-3 down at half-time to claim a record 12th consecutive victory and go top of the Six Nations table.
Saracens' defeat on Friday left the door ajar for Exeter Chiefs, who downed Newcastle Falcons to go top of the Premiership.
Having been thrashed by England last time out, a much-changed France side produced a fine showing to down Scotland in Paris.
Peter O'Mahony is relishing the prospect of leading Ireland out in Rome in the absence of the rested Rory Best.
New Zealand pair Richie Mo'unga and Scott Barrett scored two tries each in a convincing win for the Crusaders.
Ben Morgan's brace led Gloucester to another big victory as they fended off a fast-finishing Saracens.
Glasgow Warriors closed the gap on Munster at the top of Conference A, despite both recording wins in the latest round of Pro14 fixtures.
Wales full-back Leigh Halfpenny will play for the first time since November when the Scarlets take on the Cheetahs.
Can the Stormers do a dramatic turnaround and beat the Lions at Newlands? Can the Bulls win in Buenos Aires and can the Sharks embarrass the...
Sean Cronin has come off the bench 32 times for Ireland in the Six Nations, but he will start in Rome this weekend.
