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Manu Tuilagi and Courtney Lawes missed England's victory over South Africa, but could face the world champions this weekend.
Eben Etzebeth's foot injury is not as bad as first feared and he could yet play against France in Paris.
Gregor Townsend has called up half a dozen new players to the Scotland squad after various injuries at the weekend.
Owen Farrell has avoided suspension following his heavy hit on Andre Esterhuizen in England's win over South Africa.
Gethin Jenkins dragged a shot at goal wide after requiring assistance to keep the ball on the tee in a victorious final match.
Lyon scored all five tries in the second half in a rout of Stade Francais, while Racing 92 claimed their fourth consecutive win.
Eddie Jones backed Owen Farrell after England's narrow victory against South Africa.
Clermont Auvergne could only draw with lowly Grenoble and Toulouse took advantage by putting Bordeaux-Begles to the sword in the Top 14.
Jordan Larmour grasped his first opportunity to start for Ireland with both hands, scoring three tries and laying on another in Chicago.
Warren Gatland saw room for improvement but was encouraged by the way Wales saw off Scotland to win the Doddie Weir Cup.
