Clermont Auvergne outscored La Rochelle by three tries to one to win their first European trophy for 12 years.
Grenoble look to be heading for a relegation play-off after losing at home to their nearest rivals Agen.
Greig Laidlaw's boot and a pair of tries from Apisai Naqalevu helped Clermont Auvergne battle back to beat Stade Francais on the road.
Morgan Parra kicked 16 points but Clermont Auvergne survived a late scare against Harlequins to progress in the European Challenge Cup.
Franck Azema will become the longest-serving coach in Clermont Auvergne's history if he sees out a new deal until 2023.
Sofiane Guitoune's 77th-minute try carried Toulouse past Clermont Auvergne as the top two in the table served up a Sunday treat.
Clermont Auvergne had to settle for a draw against Racing 92, while Lyon held on to beat Pau in a thrilling day of Top... Read more
Bristol Bears and Northampton Saints were no match for La Rochelle and Clermont in the European Challenge Cup quarter-finals.
Tries from Carl Fearns, Mickael Ivaldi and Thibaut Regard helped Lyon get back to winning ways in Saturday's Top 14 action.
The Top 14's leading two both won on Sunday, but it was Toulouse's bonus-point success that grabbed the attention.
Toulouse's lead in the Top 14 table is down to a solitary point after Clermont Auvergne thrashed Grenoble. Lyon, meanwhile, lost at home.
Lyon claimed a third successive win and are breathing down Clermont's necks after beating them at Matmut Stade de Gerland,
Perpignan finally had a win to celebrate, while Clermont Auvergne were too good for Bordeaux-Begles in Top14.
Clermont had not been beaten since October, but they were brought back down to earth by Top 14 champions Castres.
Wesley Fofana will retire from France duty after this year's Rugby World Cup, but will still carry on playing for Clermont Auvergne.
Northampton scored 17 tries in a record victory as they beat Timisoara Saracens 111-3 to reach the European Challenge Cup quarter-finals.