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England prop Mako Vunipola features in their 34-man squad ahead of the game with Wales, with Jack Maunder called up.
Absent for the opening three matches of the Six Nations, Anthony Watson is back in the mix for England this week.
England were quick out of the blocks against Ireland and Owen Farrell insists the team are happy with how things are "in-house".
Ireland were beaten 24-12 at Twickenham, with head coach Andy Farrell left to concede that England were much the better side.
Eddie Jones' team selection for England's crunch Six Nations clash with Ireland raised eyebrows, but his side responded in style on Sunday.
Ireland have been forced into a late change to their team to play England, with Devin Toner in for Iain Henderson.
Lewis Moody was impressed by England's grit and determination in the win over Scotland but says Ireland will provide a far sterner test.
World Cup winner Lewis Moody says Ellis Genge would be in his starting line-up to face Ireland with Mako Vunipola unavailable.
A mouthwatering round three of the Six Nations could be pivotal in a battle for the title that appears to be wide open.
Eddie Jones says Manu Tuilagi should be fit to return against Ireland, while fellow centre Henry Slade will be monitored.
Caelan Doris has recovered from a head injury, but the Ireland number eight has to settle for a place on the bench against England.
Mako Vunipola has flown to Tonga and will not be available for England's Six Nations encounter with unbeaten Ireland this weekend.
Jamie George said he is not leaving Saracens earlier this week and England team-mate Elliot Daly is also staying put.
There was mixed news from head coach Eddie Jones for England on the injury front on Thursday.
Several Saracens stars are expected to stay despite the club's relegation from the Premiership, and Jamie George said he is going nowhere.
The RFU distanced itself from a report claiming Rassie Erasmus was being lined up to replace Eddie Jones as England head coach.
