After both recorded opening wins, Ireland and Wales clash in Dublin. Meanwhile, there's the small matter of a Calcutta Cup clash.
Josh Adams plundered a hat-trick in Wales' rout of Italy, much to the delight of his boss Wayne Pivac.
Wales opened the Six Nations by nilling Italy in Cardiff, Josh Adams and Dan Biggar starring for Wayne Pivac's side.
England and Scotland are the only sides without a new head coach for the 2020 edition of the Six Nations.
The Six Nations returns this weekend, with defending champions Wales hosting Italy, England facing France and Ireland taking on Scotland.
We use Opta data to look at Italy's time in the Six Nations as the upcoming edition marks 20 years since they first featured.
Josh Navidi is set to miss the majority of the Six Nations, while George North shifts to centre for Wales' first match of the... Read more
Wayne Pivac is hoping Liam Williams will make his comeback from an ankle injury in the second round of the Six Nations against Ireland.
Alberto Sgarbi has not played for Italy since 2014 but was named in Franco Smith's first squad selection on Monday.
Conor O'Shea stood down from his role as Italy head coach last week, and Franco Smith will take interim charge.
Italy will search for a new coach ahead of the Six Nations after Conor O'Shea resigned.
Sergio Parisse is furious with World Rugby's decision to call off Italy's match against New Zealand due to Typhoon Hagibis.
Saturday's Pool C decider between England and France will not take place due to bad weather set to hit Tokyo.
Nicola Quaglio has not escaped punishment for a tip tackle on Duane Vermeulen, while Andrea Lovotti also faced a three-game ban.
South Africa put 14-man Italy to the sword to put one foot in the quarter-finals, but Rassie Erasmus says there was room for improvement.
Ruthless South Africa moved to the top of Pool B by dishing out a seven-try hammering to Italy.