Peter O'Mahony is relishing the prospect of leading Ireland out in Rome in the absence of the rested Rory Best.
Sean Cronin has come off the bench 32 times for Ireland in the Six Nations, but he will start in Rome this weekend.
The third round of fixtures in the 2019 Six Nations sees Wales host England, Scotland visit France, and Ireland head to Italy.
Having played for Ulster last week, Iain Henderson has been named in the 34-man Ireland squad to face Italy as expected.
Having sustained a suspected concussion while playing for Top 14 at the weekend, Sergio Parisse will sit out Italy's clash with Ireland.
With Elliot Daly departing for Saracens, Wasps will hope Matteo Minozzi proves to be a 'Super Smash' signing from Zebre.
Callum Braley won successive World Rugby Under-20 Championships with England but has been named in the latest Italy training squad.
Wales' performance against Italy was not of undue concern to Warren Gatland, who hopes to set a new record when facing England next up.
Wales made it two from two in the 2019 Six Nations but captain Jonathan Davies was not wholly satisfied with their display against Italy.
It was another struggle for Wales but Warren Gatland's side battled their way to a 26-15 Six Nations win over Italy in Rome on...
Read more
Scotland can expect an Ireland backlash at Murrayfield, while England and Wales head into round two on a high after making winning starts.
With the Rugby World Cup to come later this year, Warren Gatland has used the second week of the Six Nations to get to...
Read more
Conor O'Shea has made two changes to his Italy XV ahead of hosting Wales, with Edoardo Padovani and Nicola Quaglio coming in.
Warren Gatland has made 10 changes to his starting line-up for the clash against Italy, with Jonathan Davies named as captain.
Italy have released the injured Tito Tebaldi from their Six Nations squad, while uncapped hooker Engjel Makelara has been called up.
British and Irish Lions back-row CJ Stander has been ruled out of Ireland's next two Six Nations matches.