Ryan Baird and Dave Kearney both scored hat-tricks as Conference A leaders Leinster routed Glasgow Warriors on Friday.
Cian Healy will miss the remainder of the Six Nations after the prop was injured during Ireland's loss to England.
Leinster became the first Pro14 side to win their first 12 league matches of a season after they overcame Ospreys on Friday.
The Ospreys claimed only their second Pro14 win over the season at the expense of high-flying Ulster in a stormy Swansea.
Ireland's James Ryan is hungry for more honours with club and country after signing a new deal.
Ahead of crunch Six Nations matches with Wales and England, Ireland were dealt a blow with Garry Ringrose ruled out.
Johnny Sexton and Jordan Larmour have been joined by uncapped number eight Caelan Doris in Ireland's team to face Scotland.
Johnny Sexton expects to lead Ireland against Scotland in Dublin and Jordan Larmour is expected to be in contention.
At the end of another week of crisis, Saracens had rare cause for cheer as they reached the quarter-finals of the European Champions Cup.
A thrashing of Lyon ensured Leinster made it five wins from five in the European Champions Cup, while Racing 92 reached the last eight.
Pro14's Conference A leaders Leinster dismantled second-placed Ulster on Friday, scoring eight times before the beaten visitors rallied.
Lyon are reportedly targeting Ireland fly-half Johnny Sexton, but Leinster insist there has been no suggestion he will leave the province.
Leinster head coach Leo Cullen is unsure how long fly-half Johnny Sexton will be out of action.
There were seven tries in Leinster's 43-16 European Champions Cup win over Northampton Saints as they made it 10 victories from 10.
Ospreys were no match for Saracens on Saturday, while Exeter Chiefs were among the other European Champions Cup winners.
Andrew Porter and Ronan Kelleher each crossed twice as Leinster maintained their 100 per cent record, while Edinburgh beat Dragons.