Leaders Lyon are the only unbeaten side in the Top 14 after they won a top-of-the-table encounter against Bordeaux-Begles.
Jake McIntrye amassed 22 points as Clermont Auvergne defeated Top 14 strugglers Stade Francais, as Bordeaux-Begles drew with Montpellier.
Toulon and Agen each won in the Top 14 on Sunday, with Racing 92 unable to complete a turnaround while Montpellier were outplayed.
The top two in the Top 14 both triumphed on Saturday, with Bordeaux-Begles and Lyon improving to three wins from three this season.
The second round of Top 14 fixtures saw hard-fought wins for Clermont Auvergne, La Rochelle and Montpellier, among others, on Saturday.
Lyon booked a Top 14 semi-final against Clermont after a hard-fought 21-16 victory over Montpellier on Saturday.
Neither Bordeaux Begles nor Stade Francais can make the play-offs in the Top 14 after suffering painful defeats in the penultimate round.
Handre Pollard has agreed to join Top 14 heavyweights Montpellier and Morne Steyn will return to his homeland to replace the fly-half.
Grenoble look to be heading for a relegation play-off after losing at home to their nearest rivals Agen.
Sofiane Guitoune's 77th-minute try carried Toulouse past Clermont Auvergne as the top two in the table served up a Sunday treat.
Toulon may have been at a numerical disadvantage for most of the second half but they still managed to defeat Top 14 leaders Toulouse.
Tries from Carl Fearns, Mickael Ivaldi and Thibaut Regard helped Lyon get back to winning ways in Saturday's Top 14 action.
There were big wins for 2017-18 Top 14 finalists Castres and Montpellier on Saturday, with Benjamin Urdapilleta inspiring.
Zack Holmes scored 15 points as Toulouse extended their lead at the Top 14 summit, while Stade Francais boosted their play-off hopes.
Perpignan finally had a win to celebrate, while Clermont Auvergne were too good for Bordeaux-Begles in Top14.
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