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Clermont had not been beaten since October, but they were brought back down to earth by Top 14 champions Castres.
Both Edinburgh and Glasgow Warriors are through to the European Champions Cup quarter-finals due to the former's 19-10 win over Montpellier.
All four Pro14 sides in European Rugby Champions Cup action on Saturday secured victories, three coming against French opposition.
Racing 92's win over Toulon will not have made pleasant viewing for France coach Jacques Brunel as Teddy Thomas was injured.
Toulouse ended 2018 on a high note, dishing out a crushing defeat to Toulon in one of three Top 14 games on Sunday.
Stade Francais moved up to fifth in the table as Toulon and Racing 92 ran out convincing winners in Saturday's Top 14 action.
Back-to-back wins over Newcastle Falcons have Edinburgh closing in on a quarter-final place in the European Champions Cup.
There were wins for Gloucester, Toulon and Leinster in the European Champions Cup on Saturday.
Montpellier's late rally did not deny Top 14 leaders Clermont Auvergne a 28-23 victory, while Guilhem Guirado scored a try in Toulon's win.
Guilhem Guirado will leave Toulon at the end of the current Top 14 season and join Montpellier on a three-year deal.
There was a dramatic win for Racing 92 in Top 14, as Toulouse went top but only after a battle at Pau.
Lyon scored all five tries in the second half in a rout of Stade Francais, while Racing 92 claimed their fourth consecutive win.
Clermont still lead the way in Top 14, but Stade Francais remain on their heels after a late win over Montpellier.
Maxime Medard's late try proved crucial as Toulouse beat European Champions Cup holders Leinster on Sunday.
Freddie Burns apologised after costing Bath a Champions Cup win over Toulouse with a botched try five minutes from time.