France head to Murrayfield scenting a Grand Slam and a first Six Nations title in a decade, while wounded Wales face England.
Ireland's clash with Italy in Dublin is the only Six Nations match to be postponed due to the coronavirus.
Fly-half Finn Russell will play no part in the Six Nations, but could make his Scotland return later this year.
Stuart Hogg, Chris Harris and Adam Hastings crossed as Scotland claimed their first win of the 2020 Six Nations by beating Italy.
A mouthwatering round three of the Six Nations could be pivotal in a battle for the title that appears to be wide open.
Alessandro Zanni comes back in for Dean Budd in Italy's only change for their clash with Scotland.
Scotland, who are yet to score a try in this year's Six Nations, have made three changes to their XV to face Italy in... Read more
Scotland have called up the fit-again Sam Skinner and Matt Fagerson ahead of their clash with Italy in Rome on February 22.
Finn Russell looks unlikely to play for Scotland under Gregor Townsend after a statement released by the head coach on Monday.
Scotland will be without Jonny Gray for the rest of the Six Nations as he will return to Glasgow Warriors for treatment on an... Read more
Finn Russell has criticised head coach Gregor Townsend and said "it's not really possible for me to be involved" for Scotland.
England coach Eddie Jones was far from impressed with the behaviour of some Scotland supporters as England regained the Calcutta Cup.
Prop Ellis Genge said "I hope we have shut them up" as he laid into England's critics after they beat Scotland.
Stuart Hogg made another costly mistake as England beat Scotland in an ugly Calcutta Cup clash to claim their first win of the Six... Read more
Captain Stuart Hogg is confident Scotland can let their rugby do the talking and beat England to retain the Calcutta Cup.
Gregor Townsend will consider Finn Russell's involvement in the Six Nations after the Calcutta Cup clash on Saturday.