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Eddie Jones confirmed Manu Tuilagi will not face Scotland, but is hopeful the centre will take on Ireland at Twickenham.
Tom Curry looks certain to continue at number eight for the foreseeable future and earned the backing of England coach Eddie Jones.
In-form Harlequins number eight Alex Dombrandt will play no part in the Calcutta Cup clash after being left out of England's squad.
Gregor Townsend said the door is open for Finn Russell to return to the Scotland squad, but he will not face England.
Scotland were wasteful against Ireland on Saturday, with Stuart Hogg apologetic as he departed Dublin following a huge missed opportunity.
Johnny Sexton has played only three matches since the Rugby World Cup, but Andy Farrell saw an "outstanding" display from Ireland's captain.
Ireland were below their best on Saturday but gave new head coach Andy Farrell a winning start against Scotland.
Gregor Townsend maintained there is much more to come from Scotland after their World Cup failure, and they must step up in the Six Nations.
England and Scotland are the only sides without a new head coach for the 2020 edition of the Six Nations.
The Six Nations returns this weekend, with defending champions Wales hosting Italy, England facing France and Ireland taking on Scotland.
Gregor Townsend has told Scotland to make themselves "a nightmare to deal with" when they tackle Ireland in Dublin in the Six Nations.
Johnny Sexton and Jordan Larmour have been joined by uncapped number eight Caelan Doris in Ireland's team to face Scotland.
The mercurial Finn Russell has been punished for a breach of team protocol just nine days before Scotland's first Six Nations game.
New Scotland captain Stuart Hogg proved if you don't ask, you don't get when he put himself forward to lead his country.
Johnny Sexton expects to lead Ireland against Scotland in Dublin and Jordan Larmour is expected to be in contention.
Gregor Townsend has turned to Stuart Hogg to lead Scotland in the Six Nations following Greig Laidlaw's international retirement.
