A mammoth 43-man squad has been selected for matches against Wales and England by Springboks chief Rassie Erasmus.
Saracens finished their Premiership final win over Exeter Chiefs without Owen Farrell, but his injury was not serious.
England have named four uncapped players in their starting XV to face the Baa Baas, while Danny Cipriani is among the replacements.
Teddy Thomas is back in the fold for France, but captain Guilhem Guirado will sit out the tour of New Zealand next month.
Eddie Jones believes England can make history by winning their Test series in South Africa.
Warren Whiteley's hopes of captaining the Springboks against Wales and England have been hit by a delay in his comeback from injury.
England's options for their tour of South Africa are likely to be further restricted, with Jonathan Joseph ruled out for the season.