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Fabien Galthie has handed starts to uncapped France duo Anthony Bouthier and Mohamed Haouas for the blockbuster clash with England.
Josh Navidi is set to miss the majority of the Six Nations, while George North shifts to centre for Wales' first match of the tournament.
Gregor Townsend has told Scotland to make themselves "a nightmare to deal with" when they tackle Ireland in Dublin in the Six Nations.
England boss Eddie Jones is set to be without Luke Cowan-Dickie for the opening weekend of the new Six Nations campaign.
Saracens knew they would be relegated at the end of the season, and a 70-point penalty ensures they will finish bottom of the Premiership.
Johnny Sexton and Jordan Larmour have been joined by uncapped number eight Caelan Doris in Ireland's team to face Scotland.
Ed Griffiths agreed to lead Saracens for 12 months but leaves the Premiership club just weeks after embarking on his second spell in charge.
Mark Keohane, on IOL, writes that while the name of the Bok coach has changed, nothing really has changed with World Cup-winning coach Rassie Erasmus still...
Bordeaux-Begles, nudged into second on Saturday, could not return to the Top 14 summit at Toulouse.
In their first Premiership outing since their automatic relegation was confirmed, Saracens were soundly beaten by London rivals Harlequins.
