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Worcester Warriors were unable to complete a comeback from 18-0 down at Sale Sharks as they remain winless in the Premiership.
He has not fought since January 2015 but Sonny Bill Williams plans to return to the boxing ring in December, with Steve Hansen's blessing.
All Blacks duo Brodie Retallick and Ngani Laumape will both be sidelined due to injury.
Clermont won an early top-of-the-table clash with Stade Francais, while there were also Top 14 victories for Racing 92, Toulouse and Lyon.
The Springboks look to bounce back after they suffered an away loss to the Pumas. They meet the Wallabies in a must win match in Brisbane.
Pro14 champions Leinster were defeated by last season's runners-up Scarlets in a tense clash on Saturday.
South Africa's Rassie Erasmus was frustrated with the way they allowed Australia to score tries while struggling on Saturday.
Danny Cipriani inspired Gloucester's comeback as a former Bath player denied the hosts victory at the Rec on Saturday.
Despite the late withdrawals of Adam Coleman and Israel Folau, Australia secured a hard-fought 23-18 victory over South Africa.
Argentina were beaten by New Zealand in Nelson but Agustin Creevy was encouraged by a competitive performance.
