Conor O'Shea has handed Marco Zanon his Italy debut as one of five changes for their Six Nations clash with France.
Wesley Fofana will start in his final Six Nations match as France travel to Italy looking for their second win of the 2019 tournament.
With Italy losing their last 21 Six Nations outings, Eddie Jones feels organisers should discuss changes to the tournament's structure.
England scored eight tries in a rout, but Italy head coach Conor O'Shea said: "I wouldn't get too carried away with the scoreline."
Head coach Eddie Jones says England must look after themselves on what will be a tense final weekend of the Six Nations season.
England responded to their Six Nations loss versus Wales with an emphatic defeat Italy, setting up an intriguing final weekend.
Lewis Moody says England will be wounded from a defeat to Wales that he says should never have happened.
The fourth round of fixtures in the 2019 Six Nations sees Wales visit Scotland, England take on Italy and Ireland host France.
Italy captain Sergio Parisse will make his 68th Six Nations appearance when the Azzurri face England on Saturday.
Eddie Jones has made five changes to the England team to take on Italy, Joe Cokanasiga and Ben Te'o among the players coming in.
Maro Itoje limped out of England training and Charlie Ewels has been called up as cover for the lock.
British and Irish Lions duo Maro Itoje and Jonathan Joseph, as well as former skipper Chris Robshaw, have been called up by England.
Bill Beaumont will chair a meeting in Dublin this month to discuss plans for a new annual 12-team global competition.
Conor O'Shea says Italy are making progress and there is a belief in the camp that they can turn the corner despite defeat to...
Read more
Ireland claimed maximum points in Rome, but they did not resemble Six Nations champions as Italy gave them a scare.
Italy deservedly led Ireland 16-12 at half-time in Rome, but Joe Schmidt's side just about did enough to avoid a huge Six Nations upset.