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England have confirmed a knee injury for Maro Itoje, which will definitely see him miss the France game and potentially the Wales clash.
Sonny Bill Williams has not ruled out the possibility of the 2019 Super Rugby season being his last with the Blues.
Having played in the Top 14 with Toulouse, Chris Ashton believes the pace of play in the league is harming France at international level.
A rare Aviva Stadium defeat was painful for Ireland, yet Peter O'Mahony said: "We can't be hanging around feeling sorry for ourselves."
Italy have released the injured Tito Tebaldi from their Six Nations squad, while uncapped hooker Engjel Makelara has been called up.
Wasps have confirmed Elliot Daly, who has been strongly linked with Saracens, will leave the Ricoh Arena at the end of the season.
British and Irish Lions back-row CJ Stander has been ruled out of Ireland's next two Six Nations matches.
Fraser Brown and Murray McCallum have been added to Scotland's Six Nations squad, with injury concerns over Sam Skinner and Willem Nel.
World Cup-winner Stephen Larkham has been sacked as Wallabies attack coach due to a difference in attacking strategy with Michael Cheika.
Henry Slade scored two of four England tries as they consigned Ireland to a first home defeat since November 2016.
