Eddie Jones has been forced to bring in three replacements for the upcoming series against the Springboks.
France internationals Yoann Maestri and Gael Fickou have swapped Toulouse for long-term deals at Stade Francais.
Toulon have lost experienced centre Ma'a Nonu, who will put his career on hold due to "family reasons".
After being deemed to have fielded ineligible players, Romania and Spain have appealed against Rugby World Cup qualifying sanctions.
Eddie Jones is confident England will have "opportunities" to create history in South Africa.
After handing captain Brad Barritt a new contract this week, Saracens have tied director of rugby Mark McCall down to a new deal.
In my Independent Media Rants and Raves, I rave about Schalk Brits’s colossal contribution to Saracens over the last decade and take issue with the incompetence...
Brive have announced the signing of Stuart Olding, who was released by Ulster last month despite his acquittal in a rape trial.
History will be made when Stormers flanker Siya Kolisi leads the Springboks in three home Tests against England in June.
Toulouse's Richie Gray has joined Alex Dunbar in pulling out of the Scotland squad for their June fixtures.